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When the COVID-19 pandemic swept across the world in 2020, the mRNA vaccines came to the rescue of many people—but in the ...
Called iso-A11B5C1, the new lipid nanoparticle demonstrates exceptional mRNA delivery efficiency in muscle tissues while also minimizing unintended mRNA translation in organs such as the liver and ...
Scientists from the University of Pennsylvania have developed an ideal “recipe” for ionizable lipids, which are essential components of lipid nanoparticles (LNPs), the molecules that underlie the ...
Dec 09, 2023: New lipid nanoparticle shows muscle-specific mRNA delivery, reduces off-target effects (Nanowerk News) A team of researchers based at the University of Toronto’s (U of T) Leslie Dan ...
Researchers have cooked up a new way to improve mRNA delivery, developing an optimal “recipe” for ionizable lipids — key ingredients in lipid nanoparticles (LNPs), the molecules behind the COVID-19 ...
"Within the past couple of years, there's been much more appreciation for how the lipids in nanoparticles can redirect mRNA delivery to different cells and organs," said first study author Jilian ...
Lipid nanoparticles containing acid degradable lipids transfected multiple non-liver organs after an intravenous injection and efficiently transfected brain tissue after an intracranial injection. The ...
More information: Xue, L., et al. Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery, Nature ...
Li and colleagues reported their results in PNAS, in a paper titled “Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effects ...
Of the branched lipids, CL4F 8-6 LNPs carrying Cas9 mRNA and sgRNA could achieve 54% genome editing and 77% protein reduction with a single dose of 2.5 mg kg −1.
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