eLife15h
Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi-Goutières Syndrome neuropathology
This study describes a valuable new model for in vivo manipulation of microglia, exploring how mutations in the Adar1 gene within microglia contribute to Aicardi-Goutières Syndome. The methodology is ...
eLife15h
Advantageous and disadvantageous inequality aversion can be taught through vicarious learning of others’ preferences
This cost looms even larger when one can benefit from an unequal distribution of resources, a phenomenon known as advantageous inequity—for example, receiving a higher salary than a colleague with the ...
eLife3d
NR2F2 is required in the embryonic testis for Fetal Leydig Cell development
This important study reveals a critical role of the transcription factor NR2F2 in mouse fetal Leydig cell (FLC) differentiation. With elegantly carried out experiments, the authors provide compelling ...
eLife3d
An increase in reactive oxygen species underlies neonatal cerebellum repair
This important work substantially advances our understanding of reactive oxygen species (ROS) as a regenerative signal during postnatal cerebellum repair by activating adaptive progenitor ...
eLife3d
Branched actin polymerization drives invasive protrusion formation to promote myoblast fusion during skeletal muscle regeneration
This study presents a valuable finding regarding the role of Arp2/3 and the actin nucleators N-WASP and WAVE complexes in myoblast fusion. The data presented is convincing, but it is suggested to ...
eLife4d
Capsular Polysaccharide Restrains Type VI Secretion in Acinetobacter baumannii
The type VI secretion system (T6SS) is a sophisticated, contact-dependent nanomachine involved in interbacterial competition. To function effectively, the T6SS must penetrate the membranes of both ...
eLife4d
Mechanical imbalance between normal and transformed cells drives epithelial homeostasis through cell competition
Cell competition in epithelial tissue eliminates transformed cells expressing activated oncoproteins to maintain epithelial homeostasis. Although the process is now understood to be of mechanochemical ...
eLife5d
The known unknowns of the Hsp90 chaperone
An exploration of the unanswered questions in how the molecular chaperone Hsp90 supports protein homeostasis, and how single-molecule techniques could drive future breakthroughs in answering them.
eLife4d
Reconstruction of functional olfactory sensory tissue from embryonic nasal stem cells
During the development of the olfactory epithelium (OE), olfactory sensory neurons (OSNs) express only one member of the odorant receptor (OR) gene family, and O ...
eLife7d
The fate of pyruvate dictates cell growth by modulating cellular redox potential
Pyruvate occupies a central node in carbohydrate metabolism such that how it is produced and consumed can optimize a cell for energy production or biosynthetic capacity. This has been primarily ...
eLife7d
Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth
By inhibiting the DNA polymerases, BKC enhances the endogenous RS in cancer cells, leading to increased DNA damage. IBC specifically inhibits CHK2 to prevent DNA repair. The combined use of BKC and ...
eLife10d
Otoacoustic emissions but not behavioral measurements predict cochlear-nerve frequency tuning in an avian vocal-communication specialist
Frequency analysis by the cochlea forms a key foundation for all subsequent auditory processing. Stimulus-frequency otoacoustic emissions (SFOAEs) are a potentially powerful alternative to traditional ...