More information: Xuexiang Han et al, Optimization of the activity and biodegradability of ionizable lipids for mRNA delivery via directed chemical evolution, Nature Biomedical Engineering (2024 ...

A key challenge remains finding a delivery system that enables enough of the mRNA to reach target tissues safely without causing adverse effects. Lipid nanoparticles have been studied since the ...

and are used in the creation of lipid nanoparticles (LNPs) for targeted drug delivery. DOPE-Cx can form a special structure called a "cubic phase," which helps overcome a major challenge in mRNA ...

Phospholipids are key components of cell membranes, and are used in the creation of lipid nanoparticles (LNPs) for targeted drug delivery. DOPE-Cx can form a special structure called a “cubic phase,” ...

The global lipid nanoparticles market, valued at US$ 820.51 million in 2023, is projected to experience significant growth, with an expected market valuation of US$ 2,387.98 million by 2032. This ...

Advancements in mRNA vaccine technology are reshaping medicine, addressing challenges and expanding applications from ...

the precious mRNA payload is encapsulated in lipid nanoparticles. Recent elegant cryogenic-transmission electron microscopy [Biophys J 120, 2766 (2021)] reveals that these lipid nanoparticles take the ...

This new lipid nanoparticle production system developed by Shin-Etsu Chemical and Hokkaido University is capable of small-batch and mass production ...