The discovery of a novel class of peripheral tryptophan hydroxylase (TPH) inhibitors is described. This class of TPH inhibitors exhibits excellent potency in in vitro biochemical and cell-based assays ...

Because of the increasing use of psychopharmacologic drugs known to increase serotonin neurotransmission, such as SSRIs, and the increasing incidence of polypharmacy, some predict that more cases ...

The release of the “feel-good” chemicals dopamine, serotonin, endorphins, and oxytocin are tied to specific lifestyle, exercise, and dietary choices. Here’s what triggers each one.

4. Estrogen This happy hormone helps form serotonin and protects you from irrita­bility and anxiety, keeping your mood steady. Estrogen decreases with menopause, and lifestyle factors such as smoking ...

A study carried out by Ramsay RR, Dunford C, Gillman PK, titled 'Methylene blue and serotonin toxicity: inhibition of monoamine oxidase A (MAO A) confirms a theoretical prediction', claims to have ...

Many human neurological traits are linked to variations in the gene that encodes the serotonin transporter. Murphy and Lesch describe the phenotypes of mice with altered serotonin-transporter ...

Catalytic enantioselective allylation with a chiral bisphosphoramide was applied to the synthesis of LY426965, a serotonin antagonist. The key step, addition of a 3,3-disubstituted ...

Background and aims: The mechanisms underlying intestinal secretion in rotavirus diarrhoea remain to be established. We previously reported that rotavirus evokes intestinal fluid and electrolyte ...

Interior designer Meg Braff and architect Gerard Beekman rejoin a pair of waterfront town houses to its rightful whole: a warm, richly decorated sanctuary keeping watch over the Atlantic.

A new study published in Cell Metabolism has found that intermittent fasting enhances sexual behavior in aging male mice—not by improving sperm quality or hormone levels, but by shifting brain ...

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