Steps Forward: Immunoassays for cryptic HDGFL2 flag TDP-43 proteinopathy in diverse disorders. Companies have moved a PET ligand into Phase 1 trials.

As reported in 1994, the original SOD1-G93A strain, designated G1, expressed approximately 18 copies of human SOD1, randomly inserted into the genome (Gurney et al., 1994). An unequal crossover event ...

Background Sensory Stimulation Systems, and GENUS, refer to a noninvasive procedure, i.e., a "digital therapeutic," being developed by Cognito Therapeutics. The company developed a wearable GammaSense ...

Anatomy explorers have charted a new path myeloid cells use to access the brain. On 3 June in Neuron, scientists led by Lindsay Hohsfield and Kim Green, both at the University of California, Irvine, ...

Few would challenge the notion that a physically active life is better for the body, including the brain, than one spent parked on the couch. Exercise also reportedly sharpens the mind and fends off ...

T cells have been found in the brain meninges as well (May 2021 news; Feb 2025 news), but flow cytometry and single-cell RNA sequencing confirmed that these SFO CD4+ T cells are distinct. They ...

Besides cushioning the brain, CSF washes away waste such as neurotransmitters, metabolites, and proteins, including proteins that aggregate—such as Aβ and tau. After circulating through the brain, CSF ...

To narrow down the number of scents needed for such a test, Li first ranked each of the 16 SST-ID and 40 UPSIT scents for their ability to distinguish PD/DLB from controls in three cohorts—the De Novo ...

Since February, the termination of some 2,482 grants worth $8.6 billion has shaken the scientific community, including AD researchers. Thanks to government databases and intrepid scientists tracking ...

Monocyte-derived microglia arise from hematopoietic stem cells, which divide throughout a mammal’s lifetime to generate monocytes. Over time, these stem cells accrue mutations, for example in DNM3TA, ...

To test for links between viral immune response and dementia, the researchers focused on a subgroup of 91 people with dementia and 98 healthy controls who tested negative for amyloid. They found that ...

In a healthy brain, border-associated macrophages within the dura mater and choroid plexus are replaced by circulating monocytes, while those in the leptomeninges and perivascular spaces, and also ...