The growth rate of the atmospheric abundance of methane (CH 4) reached a record high of 15.4 ppb yr −1 between 2020 and 2022, but the mechanisms driving the accelerated CH 4 growth have so far been ...

As former EPA and ORD scientists, we argue that dismantling ORD would not only jeopardize human and environmental health, but also weaken American science and global competitiveness. ORD’s vital—yet ...

Sorting cells with target metabolic functions from a mutant pool exhibiting substantial genetic diversity is often the rate-limiting step in synthetic biology. Here, we developed a label-free, ...

Natural ice plays salient roles in making the Earth habitable and sustainable. Previously overlooked, its role in chemical processes is now of emerging interest, particularly due to the freeze ...

The prostaglandin D2 receptor (DP1) functions as a critical regulator of diverse physiological processes, including sleep–wake cycles, allergic responses, and inflammatory cascades. By determining ...

Developing oral biologics has long been a holy grail of protein engineering. Traditional antibodies are large and unstable in the presence of gastrointestinal proteases. Here, we present a strategy to ...

Greening immediately after etiolated-seedling’s emergence from the soil is critical for plants to initiate their autotrophic life cycle through photosynthesis. The greening process relies on a complex ...

GAK and its chaperone protein, Hsc70, are known to be recruited to clathrin-coated vesicles (CCVs) to mediate clathrin uncoating. Previous studies have proposed that early recruitment of GAK–Hsc70 to ...

Calcineurin is a highly conserved phosphatase that plays a central role in sensing calcium and governing transcriptional, posttranscriptional, and posttranslational signaling networks. Calcineurin is ...

Physical exercise is known to reduce depression, but the underlying brain mechanisms remain unclear. Based on a chronic restraint stress model in mice, we showed that 4-wk treadmill exercise ...

Thylakoid-free cyanobacteria are thought to preserve ancestral traits of early-evolving organisms capable of oxygenic photosynthesis. However, and until recently, photosynthesis studies in ...

Scientists have long promised that AI will make more rational decisions than even expert humans. These studies show that this is not a foregone conclusion because large language models (LLMs) already ...