When the COVID-19 pandemic swept across the world in 2020, the mRNA vaccines came to the rescue of many people—but in the ...

Scientists from the University of Pennsylvania have developed an ideal “recipe” for ionizable lipids, which are essential components of lipid nanoparticles (LNPs), the molecules that underlie the ...

Penn Engineers have developed a Lipid Nanoparticle (LNP) that delivers mRNA theraputic to the placenta to treat pre-eclampsia in mice with human trials on the horizon.

More information: Xue, L., et al. Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery, Nature ...

This review discusses the hurdles of systemic siRNA delivery and highlights the recent progress made in lipid-based nanoparticles.

Researchers have cooked up a new way to improve mRNA delivery, developing an optimal “recipe” for ionizable lipids — key ingredients in lipid nanoparticles (LNPs), the molecules behind the COVID-19 ...

Learninf Objectives: Identify the advantages of using azide-acetal linkers for acid degradable lipid nanoparticles in drug delivery Compare the stability and hydrolysis rates of azide-acetal linkers ...

A new lipid nanoparticle The life-saving mRNA COVID vaccines used unique lipid nanoparticles as the mRNA delivery system. The method in this study matched up mRNA with just one unique lipid ...

A similar process happens on a microscopic scale when lipid nanoparticles (LNPs)—the technology behind COVID-19 vaccines—deliver mRNA to cells. Just as a shuttle must dock correctly to ...

As I have written about previously, the IP and competitive landscape for mRNA and lipid nanoparticles is complex. Pioneers, mid-stage, and new market entrants must take careful consideration of ...

Researchers have cooked up a new way to improve mRNA delivery, developing an optimal 'recipe' for ionizable lipids - key ingredients in lipid nanoparticles, the molecules behind the COVID-19 vaccines ...