The San Francisco 49ers’ practice schedule began a day later than normal with a Monday night showdown against the Detroit Lions coming up in Week 17. Their practice report opened with some good news on the injury front.

San Francisco 49ers running back Isaac Guerendo started the year as the team's fourth option on the depth chart. The rookie running back wasn't expected to play much if at all, this season. Unfortunately,

RB Jordan Mason filled in admirably to start the year, but he was hit with a shoulder injury in Week 6 that he battled until McCaffrey’s return in Week 10. McCaffrey and Mason were both hurt in a Week 13 loss to the Buffalo Bills, which pushed rookie fourth-round pick RB Isaac Guerendo into the starting role.

Curious to know about 49ers RB Isaac Guerendo‘s injury? The standout rookie has drawn attention for his breakout performances on the field and his determination to play despite a recent foot injury. From his impressive debut to becoming a key player in the 49ers’ backfield,

The San Francisco 49ers have been decimated by injuries all year, specifically at the running back position. Christian McCaffrey and Jordan Mason are both on injured reserve, leaving rookie Isaac Guerendo as the top back.

The rookie running back did not practice last week and has been officially ruled out of Sunday’s clash at Hard Rock stadium

San Francisco 49ers running back Isaac Guerendo appeared on Wednesday's injury report due to a hamstring issue sustained during last week's game against

The San Francisco 49ers face the Miami Dolphins this weekend and the rookie running back is now a major doubt to take part.

“49ers rookie RB Isaac Guerendo plans to play Thursday night vs. the Rams despite his sprained foot that has left him being listed as questionable, per sources. Guerendo insists he ‘feels good,'” Adam Schefter of ESPN reported in a post shared on X, formerly Twitter.