Keratinases is a special hydrolytic enzyme produced by microorganisms, which has the ability to catalyze the degradation of keratin. Currently, keratinases show great potential for application in many ...

Antibody–siRNA conjugates (ARCs) are a type of promising drug modalities for cancer therapy. However, initial reports of ARCs present the gene knockdown effect only in limited tissues (e.g., muscles) ...

Facilities operated by the US Department of Energy (DOE) are required to have extensive worker safety and health programs by regulation. We describe how Argonne National Laboratory (ANL) has ...

Metathesis and reversible catalytic reactions are fundamentally intriguing and powerful tools in modern synthetic chemistry. While most reversible catalytic reactions are predicated on breaking and ...

Opioids have been essential in pain management, particularly when other analgesics prove insufficient, but their use is complicated by risks of addiction, tolerance, and a range of adverse effects.

Here, we report a photo- and copper-catalyzed enantioselective oxidation of benzylic C(sp3)–H bonds using N-hydroxyphthalimide as the oxygenated reagent. The reaction proceeds under mild conditions ...

1,2,4-Thiadiazoles, a significant class of heterocyclic compounds, are widely found in biologically active molecules. Herein, we report a green electrochemical three-component reaction of amines, ...

3-Allylindoles constitute a key structural feature in many natural products and bioactive compounds. In this work, we developed a Mo-mediated reductive cyclization ...

Although the most commonly used method for enhancing a limit of detection (LoD) in immunoassay is adopting chemiluminescence (CL), the liquid form of CL substrates has hindered its use for rapid ...

Micropatterning quantum dots (QDs) is a key process for making high-performance quantum dot light-emitting diodes (QLEDs), which have shown advantages in lighting and displays. So far, various ...

Heterogeneous catalysis is a surface phenomenon where the adsorption, desorption, and transfer of reactants and products are critical for catalytic performance. Recent results show that catalyst ...

Nanoaperture optical tweezers allow for trapping single proteins and detecting their conformational changes without modifying the protein, i.e., being free from labels or tethers. While past works ...